Arranging and combining multiple plots and graphics

Question

I have 4 plots/schematics. They are either created with ArrayPlot[], ParametricPlot3D[] or Graphics[]. As I play with calculation resolutions their absolute sizes will change. I would like a neat way to arrange them inside a YouTube sized box (1920 x 1080) using relative positioning so that when/if they change size the final combination still looks more or less how I want.

To simplify the question let's say I have:

videoBox = Graphics[{EdgeForm[Thick], White, Rectangle[{0, 0}, {1920,1080}]}];
plot1 = Graphics[{Blue, Rectangle[{0, 0}, {2, 3}]}];
plot2 = Graphics[{Red, Disk[{0, 0}, 2]}];
plot3 = Graphics[{Orange, Disk[{0, 0}, 2]}];
plot4 = Graphics[{Gray, Rectangle[{0, 0}, {2, 1}]}];
GraphicsRow[{videoBox, plot1, plot2, plot3, plot4}]

Using relative positioning I would like to combine them to look something like:

Any suggestions?

Update 1

The answers and suggestions have certainly helped, but I still need more control over the positioning. For example here is the actual image I have created using the suggestions so far:

Close but no cigar. I would like to move the blue and red dots schematic up so that the bottom lines up with the bottom of the rectangular box plot.

Answer 1

plot1 = Graphics[{Blue, Rectangle[{0, 0}, {2, 4}]}];
plot2 = Graphics[{Red, Disk[{0, 0}, 2]}];
plot3 = Graphics[{Orange, Disk[{0, 0}, 2]}];
plot4 = Graphics[{Gray, Rectangle[{0, 0}, {2, 1}]}];

GraphicsGrid[{{plot1, plot3, plot2}, {SpanFromAbove, plot4, 
   SpanFromLeft}}, Frame -> True, FrameStyle -> Thick]