Bug introduced in 12.2.0 or earlier. Fixed in 13.0.0 or earlier.
There appears to be an issue with RegionMember in Mathematica 12.2 when it comes to simple polygons and points.
poly=Polygon[{{1220.8,1293.36},{1223.43,1135.43},{1212.37,1135.54},{1214.34,980.877},{1412.85,983.389},{1410.92,1138.27},{1396.75,1138.7},{1395.27,1230.33},{1395.81,1261.74},{1384.48,1267.41},{1379.62,1279.57},{1382.03,1291.72},{1393.39,1298.2},{1392.58,1422.18},{1375.57,1416.5},{1353.66,1418.14},{1326.93,1425.42},{1293.73,1435.97},{1264.54,1435.97},{1237.81,1429.49},{1219.17,1420.58},{1218.59,1378.55},{1218.35,1361.41},{1228.9,1348.45},{1232.94,1328.98},{1230.5,1308.75}}];
pts={{1309.22,1183.11},{1380.98,1246.29}};
Graphics[{{Opacity[0.5],poly},Point@pts}]
However, this:
RegionMember[poly, pts]
results in {False,False} even though, this:
RegionMember[poly,{{1300,1300},{1350,1350}}]
works fine.