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I've got the same problem (mathematica 12, Linux Mint Mate 20) without any solution. Just now I installed version 12.1.1 and the method with file ~.Mathematica/FrontEnd/frontend.css is working now! Content of this file: * { font-size:16pt; font-family:"Griffy"; }


You can refer to this post, which has the method of customizing various fonts by modifying the core.nb file.

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