Deploy your API with public permissions or add Username and Password options to URLFetch: With[{cloudobject = FileNameJoin[{$CloudRootDirectory, "FactorIntegerAPI"}]}, CloudDeploy[ APIFunction[{"x" -> "Integer"}, FactorInteger[#x] &], cloudobject, Permissions -> "Public"]; URLFetch[URLBuild[cloudobject, {"x" -> "1"}]]]