**Analysis of the equation** It often is convenient to non-dimensionalize ODEs arising in physics, and this case is no exception. Rescale `x` and `y` by `{x -> xn xs, y[x] -> yn[xn] ys}`. Apply these transformations to the ODE, bringing the scale factors from the left side of the ODE, `(xs^2/ys)`, to the right. eqlast = (xs^2/ys) k ((e y[x]/c)^2 + 2 m*e y[x])^(3/2) /. y[x] -> yn[t] ys /. x -> xn xs /. t -> xn (* (k xs^2 (2 e m ys yn[xn] + (e^2 ys^2 yn[xn]^2)/c^2)^(3/2))/ys *) Now, choose the scale factors, `xs` and `ys`, to eliminate the multipliers of `yn[xn]` and `yn[xn]^2`. eq1 = eqlast[[1 ;; 3]] (eqlast[[4, 1, 1]])^(3/2) /. yn[xn] -> 1 /. xn -> 1 (* (2 Sqrt[2] k xs^2 (e m ys)^(3/2))/ys *) eq2 = eqlast[[1 ;; 3]] (eqlast[[4, 1, 2]])^(3/2) /. yn[xn] -> 1 /. xn -> 1 (* (k xs^2 ((e^2 ys^2)/c^2)^(3/2))/ys *) norms = FullSimplify[Solve[eq1 == 1 && eq2 == 1 && k > 0 && e > 0 && m > 0 && c > 0, {xs, ys}, Reals], k > 0 && e > 0 && m > 0 && c > 0] // Last (* {xs -> Sqrt[1/(c e k)]/(2 m), ys -> (2 c^2 m)/e} *) Inserting these expressions into the transformed ODE yields, eq = 1/xn D[xn yn[xn], {xn, 2}] == Simplify[eqlast /. %, k > 0 && e > 0 && m > 0 && c > 0] (* (2 yn'[xn] + xn yn''[xn])/xn == (yn[xn] (1 + yn[xn]))^(3/2) *) which is somewhat easier to work with than the ODE in its original form. The question seeks a solution with very small `y` at large `x`. To obtain such an asymptotic solution, assume that `y^2` is much smaller than `y` (in absolute value). Then, it is apparent that a solution exists equal to `cf xn^a`, `a` and `cf` constants. Unevaluated[1/xn D[xn yn[xn], {xn, 2}] - (yn[xn] (1 + yn[xn]))^(3/2)] /. {(1 + yn[xn]) -> 1, yn[xn] -> cf xn^a} (* a (1 + a) cf xn^(-2 + a) - (cf xn^a)^(3/2) *) For this expression to vanish, xn^(-2 + a) == xn^(3 a/2) clearly is required. In other words, `a == -4`. Then, `cf` is determined from Simplify[% /. a -> -4, cf > 0 && xn > 0] (* -(((-12 + Sqrt[cf]) cf)/xn^6) *) So, `cf == 144`, and this particular solution is `yn[xn] == 144/xn^4`. As we shall see, this is not the most general solution at large `xn`, but it does appear to be a separatrix. **Numerical Solution** With the constants given in the question, the scale factors become, norms (* {xs -> 3.46944*10^-12, ys -> 1.022*10^6} *) and the starting point of the integration, `x0`, normalized to `xs`, becomes (rationalized for future use in `NDSolve`) x0n = Rationalize[x0/xs /. norms, 0] (* 723020393/5483051 *) or about `131.865`, and the specified value of `y[x0]`, normalized to `ys`, becomes y0n = Rationalize[10^6/ys /. norms, 0] (* 33547031/34284995 *) or about `0.978476`. Conveniently, `x0n` is well away from the singularity at `xn == 0`. The problem, now, is to choose `yn'[x0n]` to that `yn[xn]` approaches the separatrix, obtained above, at large `xn`. Employing a variant on the method employed to solve question [147207][1] yields the desired value of `yn'[x0n]`. xfn = 2000; s = ParametricNDSolve[{eq, yn[x0n] == y0n, yn'[x0n] == yp0, WhenEvent[Re@yn[xn] < 120/xfn^4 || yn'[xn] > 1/100, "StopIntegration"]}, yn, {xn, x0n, xfn}, {yp0, wp}, WorkingPrecision -> wp, AccuracyGoal -> Infinity, MaxSteps -> 20000]; `WhenEvent[ ... ]` is used here to terminate integration, whenever a numerical solution veers away from the separatrix. Doing so is desirable, because one hundred or more iterations at high `WorkingPrecision` typically are needed to obtain a desired solution. A small amount of experimentation is sufficient to determine that the initial value for `yn'[x0n]` is near `-1.39`. A better approximation then is obtained from plt = Plot[Quiet@(yn[yp0, 15]["Domain"] /. s)[[1, 2]], {yp0, -1.306, -1.304}, PlotRange -> All] [![enter image description here][2]][2] The improved estimate, given by the spike in the plot, is located within the range, Cases[plt, Line[a__] :> a, Infinity] // Last; Position[%, Max[Last /@ %]][[1, 1]]; est = SetPrecision[{First[%%[[% - 1]]], First[%%[[% + 1]]]}, 45] (* {-1.30493508434085847547123648837441578507423401, -1.30493385315771526222761167446151375770568848} *) This already narrow range is reduced much further with dom[yp0_?NumericQ] := Quiet@(yn[yp0, 45]["Domain"] /. s)[[1, 2]] gg[bl0_, bu0_] := Module[{bl = N[bl0, 45], bu = N[bu0, 45], bt, db}, Do[bt = (bl + bu)/2; db = (bu - bl)/100; If[dom[bt] - dom[bt - db] > 0, bl = bt, bu = bt], {i, 120}]; bt]; (Note that `FixedPoint` could be used here instead of `Do` but appears to offer no advantage, at least for the present computation.) r2000 = gg @@ est (yn[r2000, 45][xfn] /. s) - 120/xfn^4 (* -1.30493476864289837272478679314595905244023206 *) (* 8.3663144286145423790813208786836901834*10^-17 *) About `80 sec` was used by my PC to obtain this result. Such very high precision usually is necessary when seeking a solution asymptotically approaching a separatrix. Below is a plot of the numerical result, in blue, and the separatrix, in orange. LogPlot[{yn[r2000, 45][xn] /. s, 144/xn^4}, {xn, x0n, xfn}, AxesLabel -> {"x/xs", "y/ys"}, LabelStyle -> Directive[Bold, 11], PlotRange -> All] As expected (and desired), the numerical solution is quite near the separatrix at large `xn`, even when viewed on a log plot. [![enter image description here][3]][3] [1]: https://mathematica.stackexchange.com/a/147585/1063 [2]: https://i.sstatic.net/BkEwK.png [3]: https://i.sstatic.net/BMmIp.png