On the MacBook Pro, Command+S saves the notebook. So, every few minutes, Command+S is invaluable.

What do other folks do? For example, in TexShop, when I compile my LaTeX code, the file is automatically saved. Is there such a feature for notebook and/or cell evaluation? What are my options?

It's pretty horrible if you haven't saved your work and Mathematica crashes. This is certainly something I would want to share with my students as well.

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    $\begingroup$ Look up NotebookAutoSave $\endgroup$ – J. M.'s torpor May 29 '15 at 3:52
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  • $\begingroup$ For those using Windows, if the Front End is acting up due to the kernel's unhappiness processing something, you can often terminate the kernel manually via Task Manager such that the Front End starts responding again, allowing you to save your Notebook. Just be careful not to terminate Mathematica itself, but just the kernel, or the whole process of salvaging the Front End is lost. $\endgroup$ – Ghersic Sep 5 '15 at 0:30

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