The probability that the OP seeks is known as the multivariate Normal orthant probability. Correctly, for the $n=3$ cased posed here, the general integral DOES in fact have a closed -form solution, though Mma cannot (currently) obtain it.
In particular, given a zero mean vector and variance-covariance matrix:
$$\Sigma =\left(
\begin{array}{ccc}
1 & \rho _{\text{xy}} & \rho _{\text{xz}} \\
\rho _{\text{xy}} & 1 & \rho _{\text{yz}} \\
\rho _{\text{xz}} & \rho _{\text{yz}} & 1 \\
\end{array}
\right)$$
$\dots$ the standardised trivariate Normal orthant probability is:
$$P(X>0,Y>0,Z>0) \quad = \quad \frac{1}{8} + \frac{\text{ArcSin}\left[\rho _{\text{xy}}\right]+ \text{ArcSin}\left[\rho _{\text{xz}}\right]+ \text{ArcSin}\left[\rho _{\text{yz}}\right]}{4 \pi }$$
For application and more detail, see, for instance:
Chapter 6 of our book: Rose and Smith, Mathematical Statistics with Mathematica (Section 6.4C) $\rightarrow$ a free download is available at: http://www.mathstatica.com/book/bookcontents.html , or
Stuart and Ord (1994), Kendall's Advanced Theory of Statistics (6th edition): section 15.10 and 15.11.
Example
Let $(X,Y,Z)$ have a standardised multivariate Normal with zero mean vector, and variance covariance matrix:
sigma = {{1, 27/34, 22/23}, {27/34, 1, 4/5}, {22/23, 4/5, 1}}
Then, the exact orthant probability is given immediately as:
P3 = 1/8 + (ArcSin[27/34] + ArcSin[22/23] + ArcSin[4/5])/(4 Pi)
... which, to 10 decimal places, is:
N[P3, 10]
0.3732564868
By contrast, the approach using numerical integration can be unreliable here:
NIntegrate[ PDF[MultinormalDistribution[{0, 0, 0}, sigma], {x, y, z}], {x, 0, Infinity}, {y, 0, Infinity}, {z, 0, Infinity}]
NIntegrate::slwcon: Numerical integration converging too slowly ...
0.371907
Numerical integration can sometimes be awkward, unreliable, or slow (as in this example) ... and having an exact closed-form instantaneous solution is a better way to proceed, if possible.
From general to standardised
Given a zero mean vector, what if our variance-covariance matrix is not in a standardised form (with 1's along the main diagonal)? We can easily convert it into standardised form. If, say, our variance-covariance matrix is:
sigma = {{3, 1/3, 3/2}, {1/3, 2/3, -1}, {3/2, -1, 4}}
... then the standardised variance-covariance matrix S
is:
A = DiagonalMatrix[Diagonal[sigma]^(-(1/2))];
S = A.sigma.A
All done.