eqns = {s == (\[Tau][1, 2] \[Tau][3, 4] \[Tau][5, 6])/( \[Tau][1, 6] \[Tau][2, 3] \[Tau][4, 5]), \[Chi]1 == (\[Tau][1, 2] \[Tau][3,4])/(\[Tau][1, 3] \[Tau][2, 4]), \[Chi]2 == (\[Tau][3, 4] \[Tau][5, 6])/(\[Tau][3, 5] \[Tau][4, 6]), \[Chi]3 == (\[Tau][1,2] \[Tau][5, 6])/(\[Tau][1, 6] \[Tau][2, 5])} /. \[Tau][x_,y_] -> \[Tau][x] - \[Tau][y]
Note that we can add a constant to all variables $\tau_i$ without affecting the variables $s$, $\chi_1$, $\chi_2$, $\chi_3$. So let's set $\tau_6 \to 0$ (i.e., add $-\tau_6$ to all of the $\tau_i$):
modeqns = eqns /. {\[Tau][6] -> 0}
We can then get rules for eliminating $\tau_1$, $\tau_3$, and $\tau_5$ via last three equations. (I picked these three because of the symmetry of the equations.)
tausol = Solve[Drop[modeqns, 1], {\[Tau][1], \[Tau][3], \[Tau][5]}];
If we then apply this to the right-hand side of the first equation, we can see if $\tau_1$ and $\tau_5$ remain:
ssoln = FullSimplify[modeqns[[1, 2]] /. tausol]

We are (somewhat) in luck! If $\tau_1$ or $\tau_5$ had remained in this expression, we would have concluded that we could not write $s$ as a function of the $\chi_i$'s alone; but since they do not appear, we can conclude that this is the correct expression for $s$. However, we have two possible solutions; this is because the equations for $\tau_1$, $\tau_3$, and $\tau_5$ are quadratic in these variables.
However, this implies that we can find a quadratic polynomial in $s$ which the quantities $s$, $\chi_1$, $\chi_2$, and $\chi_3$ always satisfy:
poly = Collect[Together[(s - ssoln[[1]]) (s - ssoln[[2]])], s, Simplify]
(* s^2 - (\[Chi]1 \[Chi]2 \[Chi]3)/((-1 + \[Chi]1) (-1 + \[Chi]2))
+ ( s (\[Chi]1 \[Chi]2 (-1 + \[Chi]3) - \[Chi]1 \[Chi]3 - \[Chi]2 \[Chi]3))/((-1 + \[Chi]1) (-1 + \[Chi]2)) *)
So we should always have
$$
s^2 + \left[\frac{ \chi_1 \chi_2 \chi_3 - \chi_1 \chi_2 - \chi_2 \chi_3 - \chi_1 \chi_3}{(\chi_1 - 1)(\chi_2 - 1)} \right] s - \frac{\chi_1 \chi_2 \chi_3}{(\chi_1 - 1)(\chi_2 - 1)} = 0.
$$
Let's check:
rules = eqns /. Equal -> Rule;
FullSimplify[poly /. rules]
(* 0 *)
Notes:
In a previous version of this answer, I had found a unique answer for $s$ in terms of the $\chi_i$'s, but I now believe that I (or Mathematica) had been discarding one of the above two roots, and so my expression only held about half the time when I plugged in random values for the $\tau_i$ variables.
It's also not entirely clear to me why the above expression is not symmetric under the exchange of the $\chi_i$'s, given the symmetry of the equations. I will think on this further.