Since this can be readily solved analytically using seperation of variables, another option is to use the analytical solution, and replace the paramaters in the solution without the need to solve it each time.
Mathematica can't solve this analytically, but the analytical solution is
$$
u \left( x,t \right) =\sum _{n=1}^{\infty }-4\,{\frac {\sin \left( nx
\right) {{\rm e}^{t \left( -\alpha\,{n}^{2}+a \right) }} \left(
\left( -1 \right) ^{n}-1 \right) }{\pi\,{n}^{3}}}
$$
Using the above you could do
ClearAll[u, t, x, alpha, a];
nTerms = 20; (*more than enough terms*)
u = Sum[- 4 Sin[n x] Exp[t (-alpha*n^2 + a)] ((-1)^n - 1)/(Pi*n^3), {n, 1, nTerms}];
Manipulate[
Quiet@Plot[Evaluate[u /. {t -> t0, alpha -> alpha0, a -> a0}], {x, 0,Pi},
PlotRange -> {{0, Pi}, {0, 3}}, GridLines -> Automatic,
GridLinesStyle -> LightGray,
PlotStyle -> Red
],
{{t0, 0, "time"}, 0, 1, .001, Appearance -> "Labeled"},
{{alpha0, 1.68, "alpha"}, 0, 2, .01, Appearance -> "Labeled"},
{{a0, 0.5, "a"}, 0, 2, .01, Appearance -> "Labeled"}
]
