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I first updated Mathematica from a previous version (11.0.1) to the newest (11.3) and any computation requiring the kernel would make the software freeze. To solve the problem I tried completely uninstalling all the versions, and reinstalling from a freshly re-downloaded archive: no change, impossible to use Mathematica.

Is there any know issue/fix about some incompatibilities with this version?

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After some investigation, it appears that Avira's "Real-time protection" is somehow interfering with the execution of the kernel; the process savapi was using all the resources. By disabling it or uninstalling Avira, the execution works fine.

(Note that Avira also slows down the startup of Matlab)

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