# Frame plot axis labels: superscripts and subscripts in italic and non-italic

I want to make nice plot labels with framed plot.

I need to have labels with both subscripts and superscripts, both of which need to contain italic and non-italic characters.

For example $a_{b, c}^{d, e}$ label on x-axis. How to manipulate so (for example) $b, d$ are italic and $c, e$ non-italic?

My wrong code:

Plot[Sin[x],{x,0,6Pi}, Frame->True, FrameLabel->{Style["Subscript[a, b, c]^(d, e)"]}]


Thanks for help.

Plot[Sin[x], {x, 0, 6 Pi}, Frame -> True,