This may be considered a duplicate of Assign the results from a Solve to variable(s) which despite different formulation shares the same shortest answer:

Set @@@ {{a, 6}, {b, ff}, {c, 2}}

This may also be related to Reassign values to symbols if you expect to be able to make different assignments to the same Symbols in the same way. I mean that if you attempt a second series of assignments in the same manner it will not work:

Set @@@ {{a, 5}, {b, Pi}, {c, 7/3}}

Set::setraw: Cannot assign to raw object 6. >>

Set::setraw: Cannot assign to raw object 2. >>

An alternative form that will work requires keeping the assignment pairs in Hold:

List @@ Set @@@ Hold[{a, 5}, {b, Pi}, {c, 7/3}];

{a, b, c}

{5, π, 7/3}

Also related:

• Assigning values to a list of variable names
• How to create symbols from strings and set values for them?
• Elegant manipulation of the variables list

This may be considered a duplicate of Assign the results from a Solve to variable(s) which despite different formulation shares the same shortest answer:

Set @@@ {{a, 6}, {b, ff}, {c, 2}}

This may also be related to Reassign values to symbols if you expect to be able to make different assignments to the same Symbols in the same way. I mean that if you attempt a second series of assignments in the same manner it will not work:

Set @@@ {{a, 5}, {b, Pi}, {c, 7/3}}

Set::setraw: Cannot assign to raw object 6. >>

Set::setraw: Cannot assign to raw object 2. >>

An alternative form that will work requires keeping the assignment pairs in Hold:

List @@ Set @@@ Hold[{a, 5}, {b, Pi}, {c, 7/3}];

{a, b, c}

{5, π, 7/3}

Also related:

• Assigning values to a list of variable names
• How to create symbols from strings and set values for them?
• Elegant manipulation of the variables list