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Here is the answer from Wolfram Technical Support 12-bit TIFF files are not currently supported by Mathematica. Our developers are interested in supporting this format, however, and I have filed a suggestion on your behalf. I have also included your contact information so that you can be notified if this gets implemented.


If you're command line friendly, one possible workaround is to use imagemagick or one of the various libtiff command line tools to turn your image into 16-bit, viz.--- Import["12_bit.tif"] (* $Failed *) Run["/usr/local/bin/convert 12_bit.tif -depth 16 16_bit.tif"] (* 0 *) Import["16_bit.tif"] (* sweet sweet success *) On the Mac, I have imagemagick and ...

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