WolframAlpha is a built-in symbol in MMA8, yet expressions with WolframAlpha and the equal sign operator remains unevaluated despite the internet connection.
WolframAlpha["2+1"]
(* WolframAlpha["2+1"] *)
= heart disease risk 50yo male
(* AlphaIntegration`ExtrusionEvaluate["heart disease risk 50yo male", TextForm] *)
?AlphaIntegration
(* Information::notfound: Symbol AlphaIntegration not found. >> *)
?

= heart disease....but I received an answer (5.4%). Same thing happens to me sometimes, too. I usually wait a couple minutes then everything works fine. I suspect it's not MMA's fault. – VF1 Oct 9 '12 at 0:48?AlphaIntegration, evidently expecting it to work. I was simply trying to provide an explanation as to why it doesn't. Your overall problem is pretty clearly an anomaly or bug specific to your system; as VF1 suggests, I'd recommend waiting and trying again later. Or perhaps at a different location, or perhaps even reinstalling eventually. – Mark McClure Oct 9 '12 at 1:16